Role of excitation-contraction coupling in muscle fatigue
The force produced by muscles declines during prolonged activity and this decline arises largely from processes within the muscle. At a cellular level the reduced force could be caused by: (a) reduced intracellular calcium release during activity; (b) reduced sensitivity of the myofilaments to calcium; or (c) reduced maximal force development. Experiments involving intracellular calcium measurements in isolated single fibres show that all 3 of the above contribute to the decline of force during fatigue. Metabolic changes associated with fatigue are probably involved in each of the 3 factors. Thus the accumulation of phosphate and protons which occur during fatigue cause a reduction in calcium sensitivity and a decline in maximal force. The cause of the reduced intracellular calcium during contractions in fatigue is less clear. During prolonged tetani the conduction of the action potential in the T-tubules appears to fail leading to reduced intracellular calcium in the central part of the muscle fibre. However, during repeated tetani there is a uniform decline of intracellular calcium across the fibre and this remains one of the least understood processes which contribute to fatigue.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
1992 |
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| Erschienen: |
1992 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
Sports medicine (Auckland, N.Z.) - 13(1992), 2 vom: 25. Feb., Seite 116-26 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Allen, D G [VerfasserIn] |
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| Themen: |
131-99-7 |
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| Anmerkungen: |
Date Completed 11.05.1992 Date Revised 13.11.2018 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM012950459 |
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| 100 | 1 | |a Allen, D G |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Role of excitation-contraction coupling in muscle fatigue |
| 264 | 1 | |c 1992 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 11.05.1992 | ||
| 500 | |a Date Revised 13.11.2018 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The force produced by muscles declines during prolonged activity and this decline arises largely from processes within the muscle. At a cellular level the reduced force could be caused by: (a) reduced intracellular calcium release during activity; (b) reduced sensitivity of the myofilaments to calcium; or (c) reduced maximal force development. Experiments involving intracellular calcium measurements in isolated single fibres show that all 3 of the above contribute to the decline of force during fatigue. Metabolic changes associated with fatigue are probably involved in each of the 3 factors. Thus the accumulation of phosphate and protons which occur during fatigue cause a reduction in calcium sensitivity and a decline in maximal force. The cause of the reduced intracellular calcium during contractions in fatigue is less clear. During prolonged tetani the conduction of the action potential in the T-tubules appears to fail leading to reduced intracellular calcium in the central part of the muscle fibre. However, during repeated tetani there is a uniform decline of intracellular calcium across the fibre and this remains one of the least understood processes which contribute to fatigue | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 7 | |a Calcium Channels |2 NLM | |
| 650 | 7 | |a Inosine Monophosphate |2 NLM | |
| 650 | 7 | |a 131-99-7 |2 NLM | |
| 650 | 7 | |a Adenosine Monophosphate |2 NLM | |
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| 650 | 7 | |a Adenosine Triphosphate |2 NLM | |
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| 650 | 7 | |a Calcium |2 NLM | |
| 650 | 7 | |a SY7Q814VUP |2 NLM | |
| 700 | 1 | |a Westerblad, H |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, J A |e verfasserin |4 aut | |
| 700 | 1 | |a Lännergren, J |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Sports medicine (Auckland, N.Z.) |d 1993 |g 13(1992), 2 vom: 25. Feb., Seite 116-26 |w (DE-627)NLM012950440 |x 1179-2035 |7 nnns |
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