Monoclonal antibody MON-114 : detection of a marker for neuroendocrine differentiation in human lung cancer
Mouse monoclonal antibody MON-114 was generated upon immunization with a human small cell lung carcinoma cell line GLC-19. Immunohistochemical analysis of normal tissues with MON-114 showed staining of the adrenal gland, brain and peripheral nerves. With respect to human lung carcinomas, 7 out of 8 small cell lung carcinomas were positively stained as well as 5 out of 5 carcinoid tumors, whereas only 4 out of 31 squamous cell carcinomas and 3 out of 19 adenocarcinomas were weakly stained. Furthermore, 1 large cell carcinoma was negative for MON-114 staining. Apparently, MON-114 stains cells of neuroendocrine differentiation.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
1992 |
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| Erschienen: |
1992 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:63 |
|---|---|
| Enthalten in: |
Cancer letters - 63(1992), 1 vom: 31. März, Seite 61-6 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
van Duijnhoven, H L [VerfasserIn] |
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| Themen: |
Antibodies, Monoclonal |
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| Anmerkungen: |
Date Completed 07.05.1992 Date Revised 20.07.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM012943681 |
|---|
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| 041 | |a eng | ||
| 100 | 1 | |a van Duijnhoven, H L |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Monoclonal antibody MON-114 |b detection of a marker for neuroendocrine differentiation in human lung cancer |
| 264 | 1 | |c 1992 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 07.05.1992 | ||
| 500 | |a Date Revised 20.07.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Mouse monoclonal antibody MON-114 was generated upon immunization with a human small cell lung carcinoma cell line GLC-19. Immunohistochemical analysis of normal tissues with MON-114 showed staining of the adrenal gland, brain and peripheral nerves. With respect to human lung carcinomas, 7 out of 8 small cell lung carcinomas were positively stained as well as 5 out of 5 carcinoid tumors, whereas only 4 out of 31 squamous cell carcinomas and 3 out of 19 adenocarcinomas were weakly stained. Furthermore, 1 large cell carcinoma was negative for MON-114 staining. Apparently, MON-114 stains cells of neuroendocrine differentiation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Antibodies, Monoclonal |2 NLM | |
| 650 | 7 | |a Antigens, Neoplasm |2 NLM | |
| 650 | 7 | |a Biomarkers, Tumor |2 NLM | |
| 700 | 1 | |a Moors, E H |e verfasserin |4 aut | |
| 700 | 1 | |a Groeneveld, A |e verfasserin |4 aut | |
| 700 | 1 | |a Timmer, E D |e verfasserin |4 aut | |
| 700 | 1 | |a de Leij, L F |e verfasserin |4 aut | |
| 700 | 1 | |a Wagenaar, S S |e verfasserin |4 aut | |
| 700 | 1 | |a Polak, J M |e verfasserin |4 aut | |
| 700 | 1 | |a van de Ven, W J |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cancer letters |d 1976 |g 63(1992), 1 vom: 31. März, Seite 61-6 |w (DE-627)NLM000147273 |x 1872-7980 |7 nnns |
| 773 | 1 | 8 | |g volume:63 |g year:1992 |g number:1 |g day:31 |g month:03 |g pages:61-6 |
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