Photosensitivity of 8BrcGMP-induced conductance in ROS-excised patches

Inside-out patches from ROS plasma membranes contain the basic enzymes of the phototransduction cascade. Similar to a native photoreceptor cell, such patches are capable of responding to light, the effect of which suppresses the cGMP-activated current. Photoresponses are observed only in the presence of GTP, whereas ATP essentially accelerates the current recovery to a dark level. Photoresponses are also observed in the presence of 8BrcGMP. Phosphodiesterase (PDE) hydrolyzes 8BrcGMP two orders of magnitude slower than cGMP, so the light inhibition of the 8BrcGMP-induced current cannot be accounted for by PDE activation. It seems that activity of cGMP-gated channels depends not only on cGMP concentration, but is additionally controlled by some other regulatory mechanisms.

Medienart:

Artikel

Erscheinungsjahr:

1992

Erschienen:

1992

Enthalten in:

Zur Gesamtaufnahme - volume:305

Enthalten in:

FEBS letters - 305(1992), 3 vom: 06. Juli, Seite 174-6

Sprache:

Englisch

Beteiligte Personen:

Kosolapov, A V [VerfasserIn]
Khalifa-Zade, M Ch [VerfasserIn]
Kolesnikov, S S [VerfasserIn]

Themen:

1-Methyl-3-isobutylxanthine
31356-94-2
8-bromocyclic GMP
Cyclic GMP
H2D2X058MU
Journal Article
TBT296U68M

Anmerkungen:

Date Completed 19.05.1993

Date Revised 20.06.2019

published: Print

Citation Status MEDLINE

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM012649554