Changes in platelet membrane glycoproteins during blood bank storage
The literature on membrane glycoprotein changes occurring during platelet storage is reviewed. Technical problems which may have biased reports are clarified, and the consensus of current studies is established. The membrane alterations that occur during blood bank storage are reminiscent of the surface changes which result from platelet secretion: an increased surface concentration of GP IIb-IIIa and GMP-140, and the appearance of platelet membrane microparticles in the supernatant plasma. The clinical importance of these changes is unknown. Future directions for research on the structure and function of stored platelets are discussed.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
1992 |
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| Erschienen: |
1992 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:18 |
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| Enthalten in: |
Blood cells - 18(1992), 3 vom: 22., Seite 501-11; discussion 512-5 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
George, J N [VerfasserIn] |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 18.03.1993 Date Revised 30.11.2018 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM012641995 |
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| 100 | 1 | |a George, J N |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Changes in platelet membrane glycoproteins during blood bank storage |
| 264 | 1 | |c 1992 | |
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| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 18.03.1993 | ||
| 500 | |a Date Revised 30.11.2018 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The literature on membrane glycoprotein changes occurring during platelet storage is reviewed. Technical problems which may have biased reports are clarified, and the consensus of current studies is established. The membrane alterations that occur during blood bank storage are reminiscent of the surface changes which result from platelet secretion: an increased surface concentration of GP IIb-IIIa and GMP-140, and the appearance of platelet membrane microparticles in the supernatant plasma. The clinical importance of these changes is unknown. Future directions for research on the structure and function of stored platelets are discussed | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
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| 650 | 7 | |a Platelet Membrane Glycoproteins |2 NLM | |
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