Failure of c-myc gene expression in B cells of some patients with common variable immunodeficiencies

Many reports have shown that expression of the c-myc protooncogene represents an early event of lymphocyte activation. Calcium influx and activation of protein kinase C synergistically bypass the early signal transduction of lymphocyte activation. In this study, the c-myc message of B cells or B cell lines stimulated by 12-o-tetradecanoylphorbol-13-acetate (TPA), A23187, Staphylococcus aureus Cowan I (SAC), or anti-mu was not expressed or was poorly expressed in common variable immunodeficiency (CVID) patients whose B cells did not differentiate or only poorly differentiated to SAC plus recombinant interleukin 2, whereas the c-myc message of 1 CVID patient's B cells that differentiated well in IgM secretion to SAC plus recombinant interleukin 2 was well expressed when stimulated by TPA, A23187, SAC, or anti-mu. These results suggest that an abnormality exists in the early signal transduction process on some CVID patients' B cells and that it may be in the bypass by calcium influx and direct activation of protein kinase C.

Medienart:

Artikel

Erscheinungsjahr:

1992

Erschienen:

1992

Enthalten in:

Zur Gesamtaufnahme - volume:9

Enthalten in:

Experimental and clinical immunogenetics - 9(1992), 2 vom: 15., Seite 109-16

Sprache:

Englisch

Beteiligte Personen:

Kondo, N [VerfasserIn]
Motoyoshi, F [VerfasserIn]
Kasahara, K [VerfasserIn]
Inoue, Y [VerfasserIn]
Mori, S [VerfasserIn]
Orii, T [VerfasserIn]

Themen:

37H9VM9WZL
63231-63-0
CD3 Complex
CD4 Antigens
CD8 Antigens
Calcimycin
Calcium
Immunoglobulin A
Immunoglobulin Fab Fragments
Immunoglobulin G
Immunoglobulin M
Interleukin-2
Journal Article
NI40JAQ945
RNA
SY7Q814VUP
Tetradecanoylphorbol Acetate

Anmerkungen:

Date Completed 02.03.1993

Date Revised 16.11.2017

published: Print

Citation Status MEDLINE

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM012637610