Intracranial germ cell tumours : I. Experience with platinum based chemotherapy and implications for curative chemoradiotherapy

The results of treatment with platinum based combination chemotherapy in ten patients with intracranial germ cell tumours (GCT) are presented. Two patients, treated for relapse within the central nervous system (CNS), attained partial responses of short duration. One patient with systemic relapse was successfully salvaged with chemotherapy. Seven patients received primary chemotherapy, six of whom received a 'CNS friendly' regimen consisting of vincristine, etoposide, carboplatin (VEJ) prior to craniospinal axis (CSA) irradiation. Three complete and three partial responses, and one patient with stable disease, were seen prior to irradiation. All seven patients are alive and remain disease-free at a median time of 12 months after treatment. Current treatment policy for germinomas attaining complete response to two courses of VEJ is a lowered CSA dose prescription, while non-germinomatous germ cell tumours (NGGCT) receive standard total dose CSA irradiation.

Medienart:

Artikel

Erscheinungsjahr:

1992

Erschienen:

1992

Enthalten in:

Zur Gesamtaufnahme - volume:4

Enthalten in:

Clinical oncology (Royal College of Radiologists (Great Britain)) - 4(1992), 6 vom: 01. Nov., Seite 345-50

Sprache:

Englisch

Beteiligte Personen:

Sebag-Montefiore, D J [VerfasserIn]
Douek, E [VerfasserIn]
Kingston, J E [VerfasserIn]
Plowman, P N [VerfasserIn]

Themen:

11056-06-7
5J49Q6B70F
6PLQ3CP4P3
BG3F62OND5
Bleomycin
Carboplatin
Case Reports
Cisplatin
Etoposide
Journal Article
Q20Q21Q62J
Vincristine

Anmerkungen:

Date Completed 21.01.1993

Date Revised 11.09.2019

published: Print

Citation Status MEDLINE

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM012616893