L-myc and N-myc influence lineage determination in the central nervous system

The N-myc and the L-myc proto-oncogenes are expressed during embryonal development mainly in the developing brain. Studies of their expression in single neuroepithelial cells revealed that neural precursors not yet committed to the glial or the neuronal lineage expressed both genes, but after lineage commitment they expressed either N-myc or L-myc. Moreover, enforced expression of L-myc in the neural precursor cell line 2.3D caused neuronal differentiation, while the expression of N-myc promoted glial differentiation. These results indicate that L-myc and N-myc play critical roles in lineage determination for the central nervous system.

Medienart:

Artikel

Erscheinungsjahr:

1992

Erschienen:

1992

Enthalten in:

Zur Gesamtaufnahme - volume:9

Enthalten in:

Neuron - 9(1992), 6 vom: 01. Dez., Seite 1217-24

Sprache:

Englisch

Beteiligte Personen:

Bernard, O [VerfasserIn]
Drago, J [VerfasserIn]
Sheng, H [VerfasserIn]

Themen:

103107-01-3
24937-83-5
63231-63-0
Fibroblast Growth Factor 2
Journal Article
Poly A
RNA
RNA, Messenger
Research Support, Non-U.S. Gov't

Anmerkungen:

Date Completed 21.01.1993

Date Revised 19.08.2019

published: Print

Citation Status MEDLINE

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM012616877