Childhood peripheral neuropathy with autoantibodies to myelin glycoprotein P0
The serum of a 4-year-old child with severe hypertrophic peripheral neuropathy contained high-titer polyclonal antibodies, mainly of IgG class, reacting with the 30-kd P0 glycoprotein of peripheral nerve. This was demonstrated by indirect immunofluorescence, immunoblot analysis of myelin proteins, and enzyme-linked immunosorbent assay with purified P0 glycoprotein. The antibodies did not react with myelin-associated glycoprotein, sulfated glycuronic acid-containing paragloboside (SGPG and SGLPG), or other peripheral nerve glycolipids or gangliosides. To our knowledge this is the first report of strong antibody activity specifically directed against P0. This antibody may play a causative role in the pathogenesis of the peripheral neuropathy in this patient.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
1992 |
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| Erschienen: |
1992 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:32 |
|---|---|
| Enthalten in: |
Annals of neurology - 32(1992), 5 vom: 01. Nov., Seite 700-2 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ben Jelloun-Dellagi, S [VerfasserIn] |
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| Themen: |
Autoantibodies |
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| Anmerkungen: |
Date Completed 29.12.1992 Date Revised 17.11.2004 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM012605670 |
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| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM012605670 | ||
| 003 | DE-627 | ||
| 005 | 20231221053045.0 | ||
| 007 | tu | ||
| 008 | 231221s1992 xx ||||| 00| ||eng c | ||
| 028 | 5 | 2 | |a pubmed24n0042.xml |
| 035 | |a (DE-627)NLM012605670 | ||
| 035 | |a (NLM)1280408 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Ben Jelloun-Dellagi, S |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Childhood peripheral neuropathy with autoantibodies to myelin glycoprotein P0 |
| 264 | 1 | |c 1992 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 29.12.1992 | ||
| 500 | |a Date Revised 17.11.2004 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The serum of a 4-year-old child with severe hypertrophic peripheral neuropathy contained high-titer polyclonal antibodies, mainly of IgG class, reacting with the 30-kd P0 glycoprotein of peripheral nerve. This was demonstrated by indirect immunofluorescence, immunoblot analysis of myelin proteins, and enzyme-linked immunosorbent assay with purified P0 glycoprotein. The antibodies did not react with myelin-associated glycoprotein, sulfated glycuronic acid-containing paragloboside (SGPG and SGLPG), or other peripheral nerve glycolipids or gangliosides. To our knowledge this is the first report of strong antibody activity specifically directed against P0. This antibody may play a causative role in the pathogenesis of the peripheral neuropathy in this patient | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Autoantibodies |2 NLM | |
| 650 | 7 | |a Cell Adhesion Molecules, Neuronal |2 NLM | |
| 650 | 7 | |a Immunoglobulin G |2 NLM | |
| 650 | 7 | |a Immunoglobulin M |2 NLM | |
| 650 | 7 | |a Myelin P0 Protein |2 NLM | |
| 650 | 7 | |a Myelin Proteins |2 NLM | |
| 700 | 1 | |a Dellagi, K |e verfasserin |4 aut | |
| 700 | 1 | |a Burger, D |e verfasserin |4 aut | |
| 700 | 1 | |a Ben Younes-Chennoufi, A |e verfasserin |4 aut | |
| 700 | 1 | |a Hentati, F F |e verfasserin |4 aut | |
| 700 | 1 | |a Steck, A |e verfasserin |4 aut | |
| 700 | 1 | |a Ben Hamida, M |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Annals of neurology |d 1983 |g 32(1992), 5 vom: 01. Nov., Seite 700-2 |w (DE-627)NLM000198420 |x 1531-8249 |7 nnns |
| 773 | 1 | 8 | |g volume:32 |g year:1992 |g number:5 |g day:01 |g month:11 |g pages:700-2 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 32 |j 1992 |e 5 |b 01 |c 11 |h 700-2 | ||