Antibodies to reverse transcriptase in HIV infection and progression to AIDS

Serum antibodies to the reverse transcriptase (ART) of human immunodeficiency virus 1 (HIV-1) were sequentially determined by ELISA in a group of 41 HIV-seropositive male homosexuals and 101 matched healthy controls, over 1.5-6 years (mean follow-up 3.25 years). Mean ART levels were significantly higher in the patient group as compared to the controls (195 +/- 75 vs. 75 +/- 45 absorbance (A) units; P less than 0.05). When analyzed in parallel with clinical evaluation and T-cell subset determinations, a "surge" in ART activity was associated with a more favourable course: eleven patients whose ART profile showed an increase greater than 100 A units (mean delta A 159.6 units) showed an attenuated decrease of CD4+ (T helper) lymphocytes with a mean time of 42.5 months to reach a CD4+ number of 400 cells/mm3. In contrast, 25 matched seropositive patients whose ART remained constant became CD4+ less than 400 cells/mm3 within a mean time of 10.8 months (P less than 0.05). These results as well as individual patients' data support a surge in serum ART as a favourable prognostic indicator, and may indicate a protective role for this antibody which should be followed up and possibly utilized in the treatment or in the design of a vaccine against HIV-1.

Medienart:

Artikel

Erscheinungsjahr:

1992

Erschienen:

1992

Enthalten in:

Zur Gesamtaufnahme - volume:33

Enthalten in:

Immunology letters - 33(1992), 2 vom: 16. Juli, Seite 207-10

Sprache:

Englisch

Beteiligte Personen:

Schattner, A [VerfasserIn]
Milchan, R [VerfasserIn]
Kaminchik, J [VerfasserIn]
Yavin, Z [VerfasserIn]
Bentwich, Z [VerfasserIn]

Themen:

EC 2.7.7.49
HIV Antibodies
HIV Reverse Transcriptase
Journal Article
RNA-Directed DNA Polymerase

Anmerkungen:

Date Completed 30.12.1992

Date Revised 24.08.2019

published: Print

Citation Status MEDLINE

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM01260397X