Relation of peak total serum bilirubin concentrations to neurodevelopmental outcome at 2 years of age in premature African neonates
As part of a wider survey of the neurodevelopmental outcome of neonates who received intensive care for various morbidities in the Middle-Belt region of Nigeria, the relationship between peak total serum bilirubin (PTSB) concentrations in the neonatal period and neurodevelopmental status at 2 years of age was evaluated in 159 children available for follow-up and assessment. The prevalence of handicaps (minor and major) increased consistently with increase in the PTSB concentration, commencing in the range of 151-200 mumol/l. Major handicaps evolved in association with PTSB concentrations above 201 mumol/l. The handicaps consisted mainly of cerebral palsy and mental retardation. Children with handicaps (minor and major) experienced greater PTSB concentrations than those with a normal neurodevelopmental outcome. The emergence of major handicaps from a mean (SD) moderate peak hyperbilirubinaemia of 241.1 (35.9) mumol/l in the African neonate is worthy of note and cause for concern.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
1992 |
|---|---|
| Erschienen: |
1992 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
|---|---|
| Enthalten in: |
Annals of tropical paediatrics - 12(1992), 3 vom: 15., Seite 249-54 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Airede, A I [VerfasserIn] |
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| Anmerkungen: |
Date Completed 11.12.1992 Date Revised 21.10.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM012601527 |
|---|
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|---|---|---|---|
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| 041 | |a eng | ||
| 100 | 1 | |a Airede, A I |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Relation of peak total serum bilirubin concentrations to neurodevelopmental outcome at 2 years of age in premature African neonates |
| 264 | 1 | |c 1992 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 11.12.1992 | ||
| 500 | |a Date Revised 21.10.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a As part of a wider survey of the neurodevelopmental outcome of neonates who received intensive care for various morbidities in the Middle-Belt region of Nigeria, the relationship between peak total serum bilirubin (PTSB) concentrations in the neonatal period and neurodevelopmental status at 2 years of age was evaluated in 159 children available for follow-up and assessment. The prevalence of handicaps (minor and major) increased consistently with increase in the PTSB concentration, commencing in the range of 151-200 mumol/l. Major handicaps evolved in association with PTSB concentrations above 201 mumol/l. The handicaps consisted mainly of cerebral palsy and mental retardation. Children with handicaps (minor and major) experienced greater PTSB concentrations than those with a normal neurodevelopmental outcome. The emergence of major handicaps from a mean (SD) moderate peak hyperbilirubinaemia of 241.1 (35.9) mumol/l in the African neonate is worthy of note and cause for concern | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Africa | |
| 650 | 4 | |a Africa South Of The Sahara | |
| 650 | 4 | |a Age Factors | |
| 650 | 4 | |a Bilirubinemia | |
| 650 | 4 | |a Biology | |
| 650 | 4 | |a Demographic Factors | |
| 650 | 4 | |a Developing Countries | |
| 650 | 4 | |a Diseases | |
| 650 | 4 | |a English Speaking Africa | |
| 650 | 4 | |a Examinations And Diagnoses | |
| 650 | 4 | |a Hemic System | |
| 650 | 4 | |a Infant | |
| 650 | 4 | |a Measurement | |
| 650 | 4 | |a Neonatal Diseases And Abnormalities | |
| 650 | 4 | |a Neurologic Effects | |
| 650 | 4 | |a Nigeria | |
| 650 | 4 | |a Physiology | |
| 650 | 4 | |a Population | |
| 650 | 4 | |a Population Characteristics | |
| 650 | 4 | |a Prevalence | |
| 650 | 4 | |a Research Methodology | |
| 650 | 4 | |a Western Africa | |
| 650 | 4 | |a Youth | |
| 650 | 7 | |a Bilirubin |2 NLM | |
| 650 | 7 | |a RFM9X3LJ49 |2 NLM | |
| 773 | 0 | 8 | |i Enthalten in |t Annals of tropical paediatrics |d 1993 |g 12(1992), 3 vom: 15., Seite 249-54 |w (DE-627)NLM012601489 |x 1465-3281 |7 nnns |
| 773 | 1 | 8 | |g volume:12 |g year:1992 |g number:3 |g day:15 |g pages:249-54 |
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| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 12 |j 1992 |e 3 |b 15 |h 249-54 | ||