Absence of noxious effects of selected neuroleptics in dominant-lethal mutagenesis assay
In a dominant-lethal assay in mice the following tricyclic neuroleptics were tested: prothiaden, imipramine, oxyprothepin decanoate and docloxythepin. No dominant-lethal effect was induced by these neuroleptics, even when administered at doses many times as great as clinical doses. The reduced percentages of pregnancies, in females who had copulated with males receiving docloxythepin, observed during and immediately after its administration, were directly connected with marked sedation induced in the males by this neuroleptic.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
1979 |
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| Erschienen: |
1979 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:66 |
|---|---|
| Enthalten in: |
Mutation research - 66(1979), 3 vom: 15. März, Seite 291-9 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Sýkora, I [VerfasserIn] |
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| Themen: |
56934-18-0 |
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| Anmerkungen: |
Date Completed 16.07.1979 Date Revised 10.12.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM000369020 |
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| 100 | 1 | |a Sýkora, I |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Absence of noxious effects of selected neuroleptics in dominant-lethal mutagenesis assay |
| 264 | 1 | |c 1979 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 16.07.1979 | ||
| 500 | |a Date Revised 10.12.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a In a dominant-lethal assay in mice the following tricyclic neuroleptics were tested: prothiaden, imipramine, oxyprothepin decanoate and docloxythepin. No dominant-lethal effect was induced by these neuroleptics, even when administered at doses many times as great as clinical doses. The reduced percentages of pregnancies, in females who had copulated with males receiving docloxythepin, observed during and immediately after its administration, were directly connected with marked sedation induced in the males by this neuroleptic | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Antipsychotic Agents |2 NLM | |
| 650 | 7 | |a Dibenzothiepins |2 NLM | |
| 650 | 7 | |a Mutagens |2 NLM | |
| 650 | 7 | |a docloxythepin |2 NLM | |
| 650 | 7 | |a 56934-18-0 |2 NLM | |
| 650 | 7 | |a Imipramine |2 NLM | |
| 650 | 7 | |a OGG85SX4E4 |2 NLM | |
| 650 | 7 | |a Dothiepin |2 NLM | |
| 650 | 7 | |a W13O82Z7HL |2 NLM | |
| 700 | 1 | |a Gandalovicová, D |e verfasserin |4 aut | |
| 700 | 1 | |a Rezábek, K |e verfasserin |4 aut | |
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| 773 | 1 | 8 | |g volume:66 |g year:1979 |g number:3 |g day:15 |g month:03 |g pages:291-9 |
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