Physicochmemical characteristics of the new antineoplastic antibiotic, nocamycin
Nocamycin is produced by Nocardiopsis syringae. It is recovered from the culture fluid by extraction with chloroform. The molecular weight of the crystalline antibiotic is 503, its melting point is 147--149 degrees, [alpha]20 degrees D = --50 degrees (c. 0.21, chloroform), lambdamax235 and 348 nm(E1%sm= = 150 and 420), the summation formula is C26 H33NO9, the biological activity is 100000 Units/mg with respect to Bacillus mycoides. Nocamycin forms salts with alkalies soluble in water. On hydrolysis with an alkali it forms carbonic acid having no ester bond (IP spectrum) and methoxylic group present in the antibiotic molecule. Nocamycin is a new natural substance.
Medienart: |
Artikel |
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Erscheinungsjahr: |
1977 |
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Erschienen: |
1977 |
Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
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Enthalten in: |
Antibiotiki - 22(1977), 6 vom: 15. Juni, Seite 486-9 |
Sprache: |
Russisch |
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Weiterer Titel: |
Fiziko-khimicheskaia kharakteristika novogo protivoopukholevogo antibiotika nokamitsina |
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Beteiligte Personen: |
Brazhnikova, M G [VerfasserIn] |
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Themen: |
63748-09-4 |
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Anmerkungen: |
Date Completed 17.09.1977 Date Revised 03.12.2021 published: Print Citation Status MEDLINE |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM000198455 |
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245 | 1 | 0 | |a Physicochmemical characteristics of the new antineoplastic antibiotic, nocamycin |
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264 | 1 | |c 1977 | |
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520 | |a Nocamycin is produced by Nocardiopsis syringae. It is recovered from the culture fluid by extraction with chloroform. The molecular weight of the crystalline antibiotic is 503, its melting point is 147--149 degrees, [alpha]20 degrees D = --50 degrees (c. 0.21, chloroform), lambdamax235 and 348 nm(E1%sm= = 150 and 420), the summation formula is C26 H33NO9, the biological activity is 100000 Units/mg with respect to Bacillus mycoides. Nocamycin forms salts with alkalies soluble in water. On hydrolysis with an alkali it forms carbonic acid having no ester bond (IP spectrum) and methoxylic group present in the antibiotic molecule. Nocamycin is a new natural substance | ||
650 | 4 | |a Journal Article | |
650 | 7 | |a Antibiotics, Antineoplastic |2 NLM | |
650 | 7 | |a Organic Chemicals |2 NLM | |
650 | 7 | |a Polyketides |2 NLM | |
650 | 7 | |a nocamycin |2 NLM | |
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700 | 1 | |a Tolstykh, I V |e verfasserin |4 aut | |
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