Physicochmemical characteristics of the new antineoplastic antibiotic, nocamycin

Nocamycin is produced by Nocardiopsis syringae. It is recovered from the culture fluid by extraction with chloroform. The molecular weight of the crystalline antibiotic is 503, its melting point is 147--149 degrees, [alpha]20 degrees D = --50 degrees (c. 0.21, chloroform), lambdamax235 and 348 nm(E1%sm= = 150 and 420), the summation formula is C26 H33NO9, the biological activity is 100000 Units/mg with respect to Bacillus mycoides. Nocamycin forms salts with alkalies soluble in water. On hydrolysis with an alkali it forms carbonic acid having no ester bond (IP spectrum) and methoxylic group present in the antibiotic molecule. Nocamycin is a new natural substance.

Medienart:

Artikel

Erscheinungsjahr:

1977

Erschienen:

1977

Enthalten in:

Zur Gesamtaufnahme - volume:22

Enthalten in:

Antibiotiki - 22(1977), 6 vom: 15. Juni, Seite 486-9

Sprache:

Russisch

Weiterer Titel:

Fiziko-khimicheskaia kharakteristika novogo protivoopukholevogo antibiotika nokamitsina

Beteiligte Personen:

Brazhnikova, M G [VerfasserIn]
Konstantinova, N V [VerfasserIn]
Potapova, N P [VerfasserIn]
Tolstykh, I V [VerfasserIn]

Themen:

63748-09-4
Antibiotics, Antineoplastic
Journal Article
Nocamycin
Organic Chemicals
Polyketides

Anmerkungen:

Date Completed 17.09.1977

Date Revised 03.12.2021

published: Print

Citation Status MEDLINE

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM000198455