Plasma and brain amino acids in fulminant hepatic failure and their relationship to hepatic encephalopathy
Amino acid concentrations were determined in plasma, whole blood, cerebrospinal fluid and brain tissue of 45 patients with grade 3 or 4 coma due to fulminant hepatic failure. The concentration of 15 of the 19 amino acids determined were significantly increased in blood and the increases were greatest for the amino acids concerned with neurotransmitter metabolism. There was no correlation, however, between the plasma concentration of these amino acids and changes in the grade of hepatic coma. The plasma concentrations of the branched chain amino acids were normal except in those patients who subsequently recovered in whom levels were slightly decreased. Phenylalanine- tyrosine and methionine were among the 15 out of 18 amino acids which were significantly increased in cerebrospinal fluid and among the 15 out of 21 amino acids which were significantly increased in the brain. The increase in tryptophan was associated with a significant elevation in brain 5-hydroxyindoleacetic acid concentration suggesting an increase in 5-hydroxytryptamine turnover in hepatic coma. Brain to plasma ratios of most amino acids in hepatic coma patients were similar to control subjects suggesting that plasma concentration is the main factor controlling the cerebral concentration. However, for the branched chain amino acids, cerebrospinal fluid and brain concentrations were increased when plasma concentrations were normal suggesting an increase in brain uptake.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
1976 |
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| Erschienen: |
1976 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:6 |
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| Enthalten in: |
European journal of clinical investigation - 6(1976), 5 vom: 10. Sept., Seite 387-94 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Record, C O [VerfasserIn] |
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| Themen: |
8DUH1N11BX |
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| Anmerkungen: |
Date Completed 23.12.1976 Date Revised 23.08.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM000108707 |
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| 100 | 1 | |a Record, C O |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Plasma and brain amino acids in fulminant hepatic failure and their relationship to hepatic encephalopathy |
| 264 | 1 | |c 1976 | |
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| 500 | |a Date Completed 23.12.1976 | ||
| 500 | |a Date Revised 23.08.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Amino acid concentrations were determined in plasma, whole blood, cerebrospinal fluid and brain tissue of 45 patients with grade 3 or 4 coma due to fulminant hepatic failure. The concentration of 15 of the 19 amino acids determined were significantly increased in blood and the increases were greatest for the amino acids concerned with neurotransmitter metabolism. There was no correlation, however, between the plasma concentration of these amino acids and changes in the grade of hepatic coma. The plasma concentrations of the branched chain amino acids were normal except in those patients who subsequently recovered in whom levels were slightly decreased. Phenylalanine- tyrosine and methionine were among the 15 out of 18 amino acids which were significantly increased in cerebrospinal fluid and among the 15 out of 21 amino acids which were significantly increased in the brain. The increase in tryptophan was associated with a significant elevation in brain 5-hydroxyindoleacetic acid concentration suggesting an increase in 5-hydroxytryptamine turnover in hepatic coma. Brain to plasma ratios of most amino acids in hepatic coma patients were similar to control subjects suggesting that plasma concentration is the main factor controlling the cerebral concentration. However, for the branched chain amino acids, cerebrospinal fluid and brain concentrations were increased when plasma concentrations were normal suggesting an increase in brain uptake | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Amino Acids |2 NLM | |
| 650 | 7 | |a Neurotransmitter Agents |2 NLM | |
| 650 | 7 | |a Tryptophan |2 NLM | |
| 650 | 7 | |a 8DUH1N11BX |2 NLM | |
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| 700 | 1 | |a Chase, R A |e verfasserin |4 aut | |
| 700 | 1 | |a Curzon, G |e verfasserin |4 aut | |
| 700 | 1 | |a Murray-Lyon, I M |e verfasserin |4 aut | |
| 700 | 1 | |a Williams, R |e verfasserin |4 aut | |
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