Theoretic significance of pH dependence of narcotics and narcotic antagonists in clinical anesthesia
Determination of the effect of pH and temperature on pKa partition, and drug distribution coefficients in a series of common narcotics and their antagonists has shown that within the range of blood pH (7.1 to 7.7) encountered in the practice of anesthesiology, marked differences of distribution of the drugs between a model lipid (octanol) and water can occur. When these data are considered in the light of clinical experience with narcotics used in patients undergoing or recovering from surgical procedures, a correlation between the depth and duration of narcosis or the efficacy of narcotic antidotes and ventilatory status is seen. This correlation can be explained in part if the influence of blood pH on the probable CNS/blood distribution of a given drug is taken into consideration. Support is given to this proposal by representative studies in the literature. The very different drug distribution coefficients of two closely related narcotic antagonists, naloxone and naltrexone, correctly predicted the faster onset and shorter duration of the former, which was confirmed by reported clinical observations.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
1976 |
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| Erschienen: |
1976 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:55 |
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| Enthalten in: |
Anesthesia and analgesia - 55(1976), 2 vom: 16. März, Seite 253-6 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Benson, D W [VerfasserIn] |
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| Themen: |
059QF0KO0R |
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| Anmerkungen: |
Date Completed 02.06.1976 Date Revised 03.07.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM000046388 |
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| 100 | 1 | |a Benson, D W |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Theoretic significance of pH dependence of narcotics and narcotic antagonists in clinical anesthesia |
| 264 | 1 | |c 1976 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
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| 500 | |a Date Completed 02.06.1976 | ||
| 500 | |a Date Revised 03.07.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Determination of the effect of pH and temperature on pKa partition, and drug distribution coefficients in a series of common narcotics and their antagonists has shown that within the range of blood pH (7.1 to 7.7) encountered in the practice of anesthesiology, marked differences of distribution of the drugs between a model lipid (octanol) and water can occur. When these data are considered in the light of clinical experience with narcotics used in patients undergoing or recovering from surgical procedures, a correlation between the depth and duration of narcosis or the efficacy of narcotic antidotes and ventilatory status is seen. This correlation can be explained in part if the influence of blood pH on the probable CNS/blood distribution of a given drug is taken into consideration. Support is given to this proposal by representative studies in the literature. The very different drug distribution coefficients of two closely related narcotic antagonists, naloxone and naltrexone, correctly predicted the faster onset and shorter duration of the former, which was confirmed by reported clinical observations | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, U.S. Gov't, Non-P.H.S. | |
| 650 | 7 | |a Narcotic Antagonists |2 NLM | |
| 650 | 7 | |a Narcotics |2 NLM | |
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| 650 | 7 | |a Pentazocine |2 NLM | |
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| 700 | 1 | |a Kaufman, J J |e verfasserin |4 aut | |
| 700 | 1 | |a Koski, W S |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Anesthesia and analgesia |d 1957 |g 55(1976), 2 vom: 16. März, Seite 253-6 |w (DE-627)NLM000025844 |x 1526-7598 |7 nnns |
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