Effects of allopurinol, propranolol and methylprednisolone on infarct size in experimental myocardial infarction
With use of a canine model of occlusion of the left anterior descending coronary artery and an intracellular lactic dehydrogenase stain to measure infarct size directly, the effects of allopurinol, methylprednisolone sodium succinate and propranolol were studied. Allopurinol did not influence the extent of myocardial necrosis, whereas both methylprednisolone and propranolol significantly reduced myocardial infarct size. Possible mechanisms of action and clinical applicability of these agents are discussed.
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
1976 |
|---|---|
| Erschienen: |
1976 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:37 |
|---|---|
| Enthalten in: |
The American journal of cardiology - 37(1976), 4 vom: 31. März, Seite 572-80 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Shatney, C H [VerfasserIn] |
|---|
| Themen: |
63CZ7GJN5I |
|---|
| Anmerkungen: |
Date Completed 02.06.1976 Date Revised 22.06.2019 published: Print Citation Status MEDLINE |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
NLM000045918 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM000045918 | ||
| 003 | DE-627 | ||
| 005 | 20231221010013.0 | ||
| 007 | tu | ||
| 008 | 231221s1976 xx ||||| 00| ||eng c | ||
| 028 | 5 | 2 | |a pubmed24n0001.xml |
| 035 | |a (DE-627)NLM000045918 | ||
| 035 | |a (NLM)3960 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Shatney, C H |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Effects of allopurinol, propranolol and methylprednisolone on infarct size in experimental myocardial infarction |
| 264 | 1 | |c 1976 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 02.06.1976 | ||
| 500 | |a Date Revised 22.06.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a With use of a canine model of occlusion of the left anterior descending coronary artery and an intracellular lactic dehydrogenase stain to measure infarct size directly, the effects of allopurinol, methylprednisolone sodium succinate and propranolol were studied. Allopurinol did not influence the extent of myocardial necrosis, whereas both methylprednisolone and propranolol significantly reduced myocardial infarct size. Possible mechanisms of action and clinical applicability of these agents are discussed | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Allopurinol |2 NLM | |
| 650 | 7 | |a 63CZ7GJN5I |2 NLM | |
| 650 | 7 | |a Propranolol |2 NLM | |
| 650 | 7 | |a 9Y8NXQ24VQ |2 NLM | |
| 650 | 7 | |a Oxygen |2 NLM | |
| 650 | 7 | |a S88TT14065 |2 NLM | |
| 650 | 7 | |a Methylprednisolone |2 NLM | |
| 650 | 7 | |a X4W7ZR7023 |2 NLM | |
| 700 | 1 | |a MacCarter, D J |e verfasserin |4 aut | |
| 700 | 1 | |a Lillehei, R C |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The American journal of cardiology |d 1958 |g 37(1976), 4 vom: 31. März, Seite 572-80 |w (DE-627)NLM000025364 |x 1879-1913 |7 nnns |
| 773 | 1 | 8 | |g volume:37 |g year:1976 |g number:4 |g day:31 |g month:03 |g pages:572-80 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 37 |j 1976 |e 4 |b 31 |c 03 |h 572-80 | ||