Tissue specific inhibition of lymphocyte proliferation by spleen extract (lymphocyte chalone) (author's transl)
Aqueous spleen extracts were purified using acetone precipitation, membrane filtration, affinity chromatography, and dialysis. These extracts were able to inhibit thymidine incorporation into lymphoid cells (MKT-CH and PHA-stimulated lymphocyte cultures). They did not influence non lymphoid tissue (melanoma cells Mel Ei 78 and Ehrlich ascites cells). The inhibition was reversible and the purified extracts were not cytotoxic. The extracts correspond to a chalone. Their importance for prevention of graft versus host reaction and for treatment of lymphoproliferative diseases is discussed.
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
1976 |
|---|---|
| Erschienen: |
1976 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:54 |
|---|---|
| Enthalten in: |
Klinische Wochenschrift - 54(1976), 5 vom: 01. März, Seite 221-6 |
| Sprache: |
Deutsch |
|---|
| Weiterer Titel: |
Gewebsspezifische Hemmung der Lymphocytenproliferation durch Milzextrakt (Lymphocytenchalon) |
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| Beteiligte Personen: |
Heidemann, E [VerfasserIn] |
|---|
| Themen: |
DNA, Neoplasm |
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| Anmerkungen: |
Date Completed 25.05.1976 Date Revised 11.07.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM000042668 |
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| 100 | 1 | |a Heidemann, E |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Tissue specific inhibition of lymphocyte proliferation by spleen extract (lymphocyte chalone) (author's transl) |
| 246 | 3 | 3 | |a Gewebsspezifische Hemmung der Lymphocytenproliferation durch Milzextrakt (Lymphocytenchalon) |
| 264 | 1 | |c 1976 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 25.05.1976 | ||
| 500 | |a Date Revised 11.07.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Aqueous spleen extracts were purified using acetone precipitation, membrane filtration, affinity chromatography, and dialysis. These extracts were able to inhibit thymidine incorporation into lymphoid cells (MKT-CH and PHA-stimulated lymphocyte cultures). They did not influence non lymphoid tissue (melanoma cells Mel Ei 78 and Ehrlich ascites cells). The inhibition was reversible and the purified extracts were not cytotoxic. The extracts correspond to a chalone. Their importance for prevention of graft versus host reaction and for treatment of lymphoproliferative diseases is discussed | ||
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a DNA, Neoplasm |2 NLM | |
| 650 | 7 | |a Growth Inhibitors |2 NLM | |
| 650 | 7 | |a Tissue Extracts |2 NLM | |
| 700 | 1 | |a Jung, A |e verfasserin |4 aut | |
| 700 | 1 | |a Wilms, K |e verfasserin |4 aut | |
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