Mechanism of action of anticonvulsants. Role of the differential effects on the active uptake of putative neurotransmitters

The effect of pentobarbital and phenytoin on the high-affinity uptake of the putative neurotransmitters gamma-aminobutyric acid (GABA), glutamate, and norepinephrine was examined in synaptosomes prepared from rat brain. Both pentobarbital and phenytoin inhibited the uptake of norepinephrine. Pentobarbital increased the uptake of GABA twofold and only slightly increased the uptake of glutamate. Phenytoin facilitated GABA uptake to a lesser extent than did pentobarbital, but also increased the uptake of glutamate. This suggests that these drugs may limit the propagation of seizures through the balance of excitatory glutamate pathways and inhibitory GABA and norepinephrine pathways. The contrasting effects of these drugs on GABA and glutamate uptake may be related to the hypnotic properties of pentobarbital not present in phenytoin.

Medienart:

Artikel

Erscheinungsjahr:

1976

Erschienen:

1976

Enthalten in:

Zur Gesamtaufnahme - volume:26

Enthalten in:

Neurology - 26(1976), 2 vom: 21. Feb., Seite 162-6

Sprache:

Englisch

Beteiligte Personen:

Weinberger, J [VerfasserIn]
Nicklas, W J [VerfasserIn]
Berl, S [VerfasserIn]

Themen:

56-12-2
6158TKW0C5
Anticonvulsants
Comparative Study
Gamma-Aminobutyric Acid
Glutamates
Hypnotics and Sedatives
I4744080IR
Journal Article
Neurotransmitter Agents
Norepinephrine
Pentobarbital
Phenytoin
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
X4W3ENH1CV

Anmerkungen:

Date Completed 30.04.1976

Date Revised 14.05.2019

published: Print

Citation Status MEDLINE

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM000034363