Mechanism of action of anticonvulsants. Role of the differential effects on the active uptake of putative neurotransmitters
The effect of pentobarbital and phenytoin on the high-affinity uptake of the putative neurotransmitters gamma-aminobutyric acid (GABA), glutamate, and norepinephrine was examined in synaptosomes prepared from rat brain. Both pentobarbital and phenytoin inhibited the uptake of norepinephrine. Pentobarbital increased the uptake of GABA twofold and only slightly increased the uptake of glutamate. Phenytoin facilitated GABA uptake to a lesser extent than did pentobarbital, but also increased the uptake of glutamate. This suggests that these drugs may limit the propagation of seizures through the balance of excitatory glutamate pathways and inhibitory GABA and norepinephrine pathways. The contrasting effects of these drugs on GABA and glutamate uptake may be related to the hypnotic properties of pentobarbital not present in phenytoin.
Medienart: |
Artikel |
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Erscheinungsjahr: |
1976 |
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Erschienen: |
1976 |
Enthalten in: |
Zur Gesamtaufnahme - volume:26 |
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Enthalten in: |
Neurology - 26(1976), 2 vom: 21. Feb., Seite 162-6 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Weinberger, J [VerfasserIn] |
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Anmerkungen: |
Date Completed 30.04.1976 Date Revised 14.05.2019 published: Print Citation Status MEDLINE |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM000034363 |
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245 | 1 | 0 | |a Mechanism of action of anticonvulsants. Role of the differential effects on the active uptake of putative neurotransmitters |
264 | 1 | |c 1976 | |
336 | |a Text |b txt |2 rdacontent | ||
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500 | |a Date Completed 30.04.1976 | ||
500 | |a Date Revised 14.05.2019 | ||
500 | |a published: Print | ||
500 | |a Citation Status MEDLINE | ||
520 | |a The effect of pentobarbital and phenytoin on the high-affinity uptake of the putative neurotransmitters gamma-aminobutyric acid (GABA), glutamate, and norepinephrine was examined in synaptosomes prepared from rat brain. Both pentobarbital and phenytoin inhibited the uptake of norepinephrine. Pentobarbital increased the uptake of GABA twofold and only slightly increased the uptake of glutamate. Phenytoin facilitated GABA uptake to a lesser extent than did pentobarbital, but also increased the uptake of glutamate. This suggests that these drugs may limit the propagation of seizures through the balance of excitatory glutamate pathways and inhibitory GABA and norepinephrine pathways. The contrasting effects of these drugs on GABA and glutamate uptake may be related to the hypnotic properties of pentobarbital not present in phenytoin | ||
650 | 4 | |a Comparative Study | |
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, U.S. Gov't, Non-P.H.S. | |
650 | 4 | |a Research Support, U.S. Gov't, P.H.S. | |
650 | 7 | |a Anticonvulsants |2 NLM | |
650 | 7 | |a Glutamates |2 NLM | |
650 | 7 | |a Hypnotics and Sedatives |2 NLM | |
650 | 7 | |a Neurotransmitter Agents |2 NLM | |
650 | 7 | |a gamma-Aminobutyric Acid |2 NLM | |
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650 | 7 | |a Pentobarbital |2 NLM | |
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650 | 7 | |a Norepinephrine |2 NLM | |
650 | 7 | |a X4W3ENH1CV |2 NLM | |
700 | 1 | |a Nicklas, W J |e verfasserin |4 aut | |
700 | 1 | |a Berl, S |e verfasserin |4 aut | |
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