Oral antipyretic therapy : evaluation of benorylate, an ester of acetylsalicylic acid and paracetamol

The capacity of benorylate, an ester of acetylsalicylic acid and paracetamol, to reduce fever in children was compared with that of the components as such or as a combination. The series of cases studied consisted of 66 patients between the ages of 4 months and 12 years with rectal temperatures above 38.5 degrees C. Temperatures were recorded at 15 and 20 min and 1, 2, 4 and 6 hrs after the administration of the drug. The antipyretic effect of combined acetylsalicylic acid (11 mg/kg) and paracetamol (14 mg/kg) was superior to the effect of benorylate with a dose of 25 mg/kg and even of 50 mg/kg as well as better than the effect of either drug alone. Acetylsalicylic acid (10 mg/kg) and paracetamol (12.5 mg/kg) alone produced a significantly greater antipyretic effect than benorylate with a dose of 25 mg/kg. Given in a dose of 35--40 mg/kg, benorylate seems to have a significant antipyretic effect. However, this effect is clearly smaller than that of either of its components, acetylsalicylic acid or paracetamol. Therefore benorylate is probably not suitable to be used as a general antipyretic agent in children.

Medienart:

Artikel

Erscheinungsjahr:

1975

Erschienen:

1975

Enthalten in:

Zur Gesamtaufnahme - volume:121

Enthalten in:

European journal of pediatrics - 121(1975), 1 vom: 09. Dez., Seite 15-20

Sprache:

Englisch

Beteiligte Personen:

Similä, S [VerfasserIn]
Keinänen, S [VerfasserIn]
Kouvalainen, K [VerfasserIn]

Themen:

362O9ITL9D
Acetaminophen
Aspirin
Comparative Study
Journal Article
R16CO5Y76E
Salicylates

Anmerkungen:

Date Completed 30.04.1976

Date Revised 13.08.2019

published: Print

Citation Status MEDLINE

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM000029726