Effects of oxygen saturation and pCO2 on brain uptake of glucose analogues in rabbits

The effect of oxygen saturation and PCO2 on brain uptake of glucose analogues was studied in rabbits. Using a modified Oldendorf technique, 14C-labeled glucose analogues with a 3H2O reference standard were introduced into the cerebral circulation via the common carotid artery, and the radioactivity of the ipsilateral cerebral cortex was counted and expressed in terms of a brain uptake index (BUI). Severe hypoxia (oxygen saturation less than or equal to 18%) resulted in approximately a 40% decrease in the BUI of 2-deoxy-D-glucose and a 45% decrease in the BUI of 3-0-methyl-D-glucose. Severe hypercapnia (PCO2 = 100 mm Hg) caused a 45% decrease in the BUI of both of these glucose analogues. Hypercapnia superimposed on severe hypoxia had no additional effect. Hypocapnia (PCO2 = 15 mm Hg) increased the BUI of 3-0-methyl-D-glucose by 35% of the control value, and this increase was extremely sensitive to competitive inhibition. When BUI values were plotted against pH rather than PCO2 for the same experiments, there was a good correlation with the calculated linear regression. These results are compared with previous findings on pathologically induced changes in brain uptake of glucose analogues, and the possible role of blood flow is considered in detail.

Medienart:

Artikel

Erscheinungsjahr:

1975

Erschienen:

1975

Enthalten in:

Zur Gesamtaufnahme - volume:6

Enthalten in:

Stroke - 6(1975), 6 vom: 18. Nov., Seite 691-6

Sprache:

Englisch

Beteiligte Personen:

Berson, F G [VerfasserIn]
Spatz, M [VerfasserIn]
Klatzo, I [VerfasserIn]

Themen:

142M471B3J
Carbon Dioxide
Glucose
IY9XDZ35W2
Journal Article
Oxygen
S88TT14065

Anmerkungen:

Date Completed 19.02.1976

Date Revised 27.07.2019

published: Print

Citation Status MEDLINE

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM000011010