Effect of two weeks' treatment with thioridazine, chlorpromazine, sulpiride and bromazepam, alone or in combination with alcohol, on learning and memory in man

Forty paid healthy male students participated in two subacute experiments of 6 weeks each. In the first trial 20 of them received bromazepam, thioridazine, and placebo double blind cross over for 2 weeks each, and in the second trial the active agents administered to the other 20 participants were chlorpromazine and sulpiride. The tests used were paired associate learning with nonsense syllables and digit memory span. Before testing the subjects took either an alcoholic or a nonalcoholic bitter drink. As in the previous study from this laboratory, alcohol was found to impair learning capacity. Of the drugs used only bromazepam impaired learning significantly, and the combined effect of alcohol and bromazepam on learning capacity was very deleterious. The adrenolytic effect of drugs did not correlate with their effect on learning. Caution is necessary when prescribing bromazepam for active outpatients at least in doses used in this study.

Medienart:

Artikel

Erscheinungsjahr:

1975

Erschienen:

1975

Enthalten in:

Zur Gesamtaufnahme - volume:44

Enthalten in:

Psychopharmacologia - 44(1975), 2 vom: 31. Okt., Seite 205-8

Sprache:

Englisch

Beteiligte Personen:

Liljequist, R [VerfasserIn]
Linnoila, M [VerfasserIn]
Mattila, M J [VerfasserIn]
Saario, I [VerfasserIn]
Seppälä, T [VerfasserIn]

Themen:

3K9958V90M
7MNE9M8287
Anti-Anxiety Agents
Bromazepam
Chlorpromazine
Clinical Trial
Controlled Clinical Trial
Ethanol
Journal Article
N3D6TG58NI
Psychotropic Drugs
Receptors, Drug
Sulpiride
Thioridazine
U42B7VYA4P
X015L14V0O

Anmerkungen:

Date Completed 09.02.1976

Date Revised 08.01.2020

published: Print

Citation Status MEDLINE

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM000009512