Lorazepam compared with pentobarbital for nighttime sedation
Lorazepam (0.5, 1, 2, and 4 mg) was compared with pentobarbital (60 and 180 mg) for its effect on sleep in "hospital insomnia." Subjective-response data were collected by research nurses. Lorazepam was found to be a potent nighttime sedative: 1 to 1.25 mg of lorazepam is equivalent to 100 mg sodium pentobarbital for measures of sleep quality and duration. At this dose level it is less effective than 100 mg of pentobarbital as a sleep inducer. Studies at higher doses (up to 4 mg) indicate that lorazepam has a wide therapeutic index.
Medienart: |
Artikel |
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Erscheinungsjahr: |
1975 |
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Erschienen: |
1975 |
Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
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Enthalten in: |
Journal of clinical pharmacology - 15(1975), 11-12 vom: 10. Nov., Seite 752-9 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Brown, P J [VerfasserIn] |
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Anmerkungen: |
Date Completed 09.02.1976 Date Revised 23.08.2019 published: Print Citation Status MEDLINE |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM000005584 |
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245 | 1 | 0 | |a Lorazepam compared with pentobarbital for nighttime sedation |
264 | 1 | |c 1975 | |
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500 | |a Date Completed 09.02.1976 | ||
500 | |a Date Revised 23.08.2019 | ||
500 | |a published: Print | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Lorazepam (0.5, 1, 2, and 4 mg) was compared with pentobarbital (60 and 180 mg) for its effect on sleep in "hospital insomnia." Subjective-response data were collected by research nurses. Lorazepam was found to be a potent nighttime sedative: 1 to 1.25 mg of lorazepam is equivalent to 100 mg sodium pentobarbital for measures of sleep quality and duration. At this dose level it is less effective than 100 mg of pentobarbital as a sleep inducer. Studies at higher doses (up to 4 mg) indicate that lorazepam has a wide therapeutic index | ||
650 | 4 | |a Comparative Study | |
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, U.S. Gov't, Non-P.H.S. | |
650 | 4 | |a Research Support, U.S. Gov't, P.H.S. | |
650 | 7 | |a Anti-Anxiety Agents |2 NLM | |
650 | 7 | |a Hypnotics and Sedatives |2 NLM | |
650 | 7 | |a Pentobarbital |2 NLM | |
650 | 7 | |a I4744080IR |2 NLM | |
650 | 7 | |a Lorazepam |2 NLM | |
650 | 7 | |a O26FZP769L |2 NLM | |
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700 | 1 | |a Brown, C R |e verfasserin |4 aut | |
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