Lorazepam compared with pentobarbital for nighttime sedation

Lorazepam (0.5, 1, 2, and 4 mg) was compared with pentobarbital (60 and 180 mg) for its effect on sleep in "hospital insomnia." Subjective-response data were collected by research nurses. Lorazepam was found to be a potent nighttime sedative: 1 to 1.25 mg of lorazepam is equivalent to 100 mg sodium pentobarbital for measures of sleep quality and duration. At this dose level it is less effective than 100 mg of pentobarbital as a sleep inducer. Studies at higher doses (up to 4 mg) indicate that lorazepam has a wide therapeutic index.

Medienart:

Artikel

Erscheinungsjahr:

1975

Erschienen:

1975

Enthalten in:

Zur Gesamtaufnahme - volume:15

Enthalten in:

Journal of clinical pharmacology - 15(1975), 11-12 vom: 10. Nov., Seite 752-9

Sprache:

Englisch

Beteiligte Personen:

Brown, P J [VerfasserIn]
Forrest, W H [VerfasserIn]
Brown, C R [VerfasserIn]

Themen:

Anti-Anxiety Agents
Comparative Study
Hypnotics and Sedatives
I4744080IR
Journal Article
Lorazepam
O26FZP769L
Pentobarbital
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Anmerkungen:

Date Completed 09.02.1976

Date Revised 23.08.2019

published: Print

Citation Status MEDLINE

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM000005584