一种SARS-CoV-2病毒的免疫原及其应用

本申请公开了一种SARS‑CoV‑2病毒的免疫原,所述免疫原包括:PreS蛋白和SARS‑CoV‑2病毒的全长S蛋白中的至少一者,其中,PreS蛋白是通过对野生型S蛋白的关键位点进行突变而形成的,PreS蛋白具有免疫性强、可诱导产生高滴度中和抗体的优点。由所述免疫原可以衍生出包括编码所述免疫原的核苷酸序列的核酸分子、包括所述核酸分子的表达盒、包括所述核酸分子或所述表达盒的表达载体、包括所述核酸分子或所述表达盒或所述表达载体的转化体、由所述核酸分子或所述表达盒或所述表达载体转染腺病毒包装细胞并进行细胞培养而获得的重组腺病毒,以及包括所述核酸分子或所述表达盒或所述表达载体或所述转化体的药物组合物。.

Medienart:

Patent

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Europäisches Patentamt - (2021) vom: 24. Dez. Zur Gesamtaufnahme - year:2021

Sprache:

Chinesisch

Links:

Volltext [kostenfrei]

Themen:

615
A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d)
A61P: Specific therapeutic activity of chemical compounds or medicinal preparations
Bio
C07K: Peptides (peptides containing β-lactam rings c07d;cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, c07d;ergot alkaloids of the cyclic peptide type c07d0519020000; single cell proteins, enzymes c12n;genetic engineering processes for obtaining peptides c12n0015000000)
C12N: Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media (microbiological testing media c12q0001000000)
C12R: Indexing scheme associated with subclasses c12c-c12q, relating to microorganisms
Che

Anmerkungen:

Source: www.epo.org (no modifications made), First posted: 2021-12-24, Last update posted on www.tib.eu: 2022-07-13, Last updated: 2023-02-09

Patentnummer:

CN112552380

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

EPA011925167