Application of sertraline hydrochloride and derivatives thereof to preparation of anti-novel-coronavirus drug
The invention relates to the technical field of medicine, and discloses application of sertraline hydrochloride and derivatives thereof to preparation of a drug for preventing and/or treating coronaviruses. A molecular formula of the sertraline hydrochloride is C17H18Cl3N, the CAS number of the sertraline hydrochloride is 79559-97-0, and the chemical name of the sertraline hydrochloride is (1S-cis)-4-(3, 4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthylamine hydrochloride. The invention finds for the first time that the sertraline hydrochloride targets SARS-CoV-2 and blocks the interaction between virus particles and a receptor so as to inhibit the SARS-CoV-2 from entering target cells; a new small molecular drug is provided for the prevention and treatment of atypical pneumonia (COVID-2019); and the small molecular drug has no cytotoxicity in the active concentration range, can inhibit the entrance of the SARS-CoV-2 in a dose-dependent manner, and can be used for preparing a medicine for preventing and/or treating the SARS-CoV-2..
Medienart: |
Patent |
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Erscheinungsjahr: |
2020 |
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Erschienen: |
2020 |
Enthalten in: |
Europäisches Patentamt - (2020) vom: 29. Dez. Zur Gesamtaufnahme - year:2020 |
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Sprache: |
Englisch |
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Beteiligte Personen: |
TAN SUIYI [VerfasserIn] |
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Links: |
Volltext [kostenfrei] |
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Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2020-12-29, Last update posted on www.tib.eu: 2022-04-10, Last updated: 2023-02-09 |
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Patentnummer: |
CN112137993 |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
EPA011330686 |
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520 | |a The invention relates to the technical field of medicine, and discloses application of sertraline hydrochloride and derivatives thereof to preparation of a drug for preventing and/or treating coronaviruses. A molecular formula of the sertraline hydrochloride is C17H18Cl3N, the CAS number of the sertraline hydrochloride is 79559-97-0, and the chemical name of the sertraline hydrochloride is (1S-cis)-4-(3, 4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthylamine hydrochloride. The invention finds for the first time that the sertraline hydrochloride targets SARS-CoV-2 and blocks the interaction between virus particles and a receptor so as to inhibit the SARS-CoV-2 from entering target cells; a new small molecular drug is provided for the prevention and treatment of atypical pneumonia (COVID-2019); and the small molecular drug has no cytotoxicity in the active concentration range, can inhibit the entrance of the SARS-CoV-2 in a dose-dependent manner, and can be used for preparing a medicine for preventing and/or treating the SARS-CoV-2. | ||
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