Application of Yb<3+>-based fluoride nanocrystal as photosensitizer in photodynamic therapy
The invention relates to application of an Yb<3+>-based fluoride nanocrystal as a photosensitizer in a photodynamic therapy and belongs to the field of the photodynamic therapy. According to the application, the problem of poor tissue penetration depth of exciting light caused by the wavelength of the exciting light of the photosensitizer in a visible region rang in the traditional photodynamic therapy is solved. The Yb<3+>-based fluoride nanocrystal is used as the photosensitizer to be applied to the photodynamic therapy. A preparation method of the Yb<3+>-based fluoride nanocrystal comprises the following steps: (1) adding YbCl3.6H2O into oleic acid and octadecene; (2) heating and dissolving; (3) adding NaOH and NH4F into methanol; (4) heating to react after mixing and water removal; (5) collecting NaYbF4 nanocrystals; (6) carrying out bond linking with Tween; and (7) carrying out bond linking with folic acid. According to the application, by irradiating by virtue of a light source with the wavelength of about 1 micron, deep tissue solid tumors can be treated by virtue of the wavelength in a biological tissue penetration window range..
| Medienart: |
|
|---|
Patent| Erscheinungsjahr: |
2016 |
|---|---|
| Erschienen: |
2016 |
| Enthalten in: |
Europäisches Patentamt - (2016) vom: 13. Jan. Zur Gesamtaufnahme - year:2016 |
|---|
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
ZHANG ZHIGUO [VerfasserIn] |
|---|
| Links: |
Volltext [kostenfrei] |
|---|
| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2016-01-13, Last update posted on www.tib.eu: 2022-04-01, Last updated: 2023-02-09 |
|---|
| Patentnummer: |
CN105233284 |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
EPA00970597X |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | EPA00970597X | ||
| 003 | DE-627 | ||
| 005 | 20230504075524.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210531s2016 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)EPA00970597X | ||
| 035 | |a (EPA)CN105233284 | ||
| 035 | |a (EPA)55031271 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 0 | |a ZHANG ZHIGUO |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Application of Yb<3+>-based fluoride nanocrystal as photosensitizer in photodynamic therapy |
| 264 | 1 | |c 2016 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Source: www.epo.org (no modifications made), First posted: 2016-01-13, Last update posted on www.tib.eu: 2022-04-01, Last updated: 2023-02-09 | ||
| 520 | |a The invention relates to application of an Yb<3+>-based fluoride nanocrystal as a photosensitizer in a photodynamic therapy and belongs to the field of the photodynamic therapy. According to the application, the problem of poor tissue penetration depth of exciting light caused by the wavelength of the exciting light of the photosensitizer in a visible region rang in the traditional photodynamic therapy is solved. The Yb<3+>-based fluoride nanocrystal is used as the photosensitizer to be applied to the photodynamic therapy. A preparation method of the Yb<3+>-based fluoride nanocrystal comprises the following steps: (1) adding YbCl3.6H2O into oleic acid and octadecene; (2) heating and dissolving; (3) adding NaOH and NH4F into methanol; (4) heating to react after mixing and water removal; (5) collecting NaYbF4 nanocrystals; (6) carrying out bond linking with Tween; and (7) carrying out bond linking with folic acid. According to the application, by irradiating by virtue of a light source with the wavelength of about 1 micron, deep tissue solid tumors can be treated by virtue of the wavelength in a biological tissue penetration window range. | ||
| 650 | 4 | |a A61P: Specific therapeutic activity of chemical compounds or medicinal preparations | |
| 650 | 4 | |a che | |
| 650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
| 650 | 4 | |a 615 | |
| 700 | 0 | |a ZHANG JIAYIN |4 aut | |
| 700 | 0 | |a QIN FENG |4 aut | |
| 700 | 0 | |a ZHAO HUA |4 aut | |
| 700 | 0 | |a ZHENG YANGDONG |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Europäisches Patentamt |g (2016) vom: 13. Jan. |
| 773 | 1 | 8 | |g year:2016 |g day:13 |g month:01 |
| 856 | 4 | 0 | |u https://worldwide.espacenet.com/patent/search/family/55031271/publication/CN105233284A1?q=CN105233284 |z kostenfrei |3 Volltext |
| 912 | |a GBV_EPA | ||
| 912 | |a SSG-OLC-PHA | ||
| 936 | u | w | |j 2016 |b 13 |c 01 |
| 951 | |a AR | ||
| 952 | |j 2016 |b 13 |c 01 | ||