SiRNA of interfering with gene expression of COVID-19 and application thereof
The invention discloses a siRNA of interfering with gene expression of a COVID-19. The siRNA is one of the following double-stranded RNA sequences: a double-stranded RNA sequence with a positive-sensestrand SEQ ID NO:5 in a sequence table and an antisense strand SEQ ID NO:6 in the sequence table, a double-stranded RNA sequence with a positive-sense strand SEQ ID NO:7 in the sequence table and anantisense strand SEQ ID NO:8 in the sequence table, and double-stranded RNA sequences which have the similarity of 95% or above to the defined double-stranded RNA sequences and have a function of silencing an RDRP gene or an S gene. The siRNA disclosed by the invention is designed for mRNA sequences of an S protein and an RDRP enzyme on the COVID-19; expression of a key protein of a virus can be effectively inhibited; and important reference significance is provided for development of an anti-COVID-19 drug..
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Patent| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Europäisches Patentamt - (2020) vom: 11. Aug. Zur Gesamtaufnahme - year:2020 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
WANG ZHEMING [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2020-08-11, Last update posted on www.tib.eu: 2022-04-09, Last updated: 2023-02-09 |
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| Patentnummer: |
CN111518809 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA005730538 |
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| 520 | |a The invention discloses a siRNA of interfering with gene expression of a COVID-19. The siRNA is one of the following double-stranded RNA sequences: a double-stranded RNA sequence with a positive-sensestrand SEQ ID NO:5 in a sequence table and an antisense strand SEQ ID NO:6 in the sequence table, a double-stranded RNA sequence with a positive-sense strand SEQ ID NO:7 in the sequence table and anantisense strand SEQ ID NO:8 in the sequence table, and double-stranded RNA sequences which have the similarity of 95% or above to the defined double-stranded RNA sequences and have a function of silencing an RDRP gene or an S gene. The siRNA disclosed by the invention is designed for mRNA sequences of an S protein and an RDRP enzyme on the COVID-19; expression of a key protein of a virus can be effectively inhibited; and important reference significance is provided for development of an anti-COVID-19 drug. | ||
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