METHODS AND COMPOSITIONS FOR TREATING CANCER
A nucleic acid sequence is provided that encodes a chimeric protein comprising a ligand that comprises a naturally occurring or modified follicle stimulating hormone sequence, e.g., an FSHβ sequence, or fragment thereof, which ligand binds to human follicle stimulating hormone (FSH) receptor, linked to either (a) a nucleic acid sequence that encodes an extracellular hinge domain, a transmembrane domain, a co-stimulatory signaling region, and a signaling endodomain; or (b) a nucleic acid sequence that encodes a ligand that binds to NKG2D. The vector containing the nucleic acid sequence, the chimeric proteins so encoded, and modified T cells expressing the chimeric protein, as well as method of using these compositions for the treatment of FSHR-expressing cancers or tumor cells are also provided..
Medienart: |
Patent |
---|
Erscheinungsjahr: |
2021 |
---|---|
Erschienen: |
2021 |
Enthalten in: |
Europäisches Patentamt - (2021) vom: 03. März Zur Gesamtaufnahme - year:2021 |
---|
Sprache: |
Englisch |
---|
Beteiligte Personen: |
PERALES-PUCHALT ALFREDO [VerfasserIn] |
---|
Links: |
Volltext [kostenfrei] |
---|
Themen: |
Sonstige Themen: |
---|
Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2021-03-03, Last update posted on www.tib.eu: 2023-07-24, Last updated: 2023-07-28 |
---|
Patentnummer: |
EP3200815 |
---|
Förderinstitution / Projekttitel: |
|
---|
PPN (Katalog-ID): |
EPA00479978X |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | EPA00479978X | ||
003 | DE-627 | ||
005 | 20230728085432.0 | ||
007 | cr uuu---uuuuu | ||
008 | 210529s2021 xx |||||o 00| ||eng c | ||
035 | |a (DE-627)EPA00479978X | ||
035 | |a (EPA)EP3200815 | ||
035 | |a (EPA)55631412 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 0 | |a PERALES-PUCHALT ALFREDO |e verfasserin |4 aut | |
245 | 1 | 0 | |a METHODS AND COMPOSITIONS FOR TREATING CANCER |
264 | 1 | |c 2021 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a Computermedien |b c |2 rdamedia | ||
338 | |a Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Source: www.epo.org (no modifications made), First posted: 2021-03-03, Last update posted on www.tib.eu: 2023-07-24, Last updated: 2023-07-28 | ||
520 | |a A nucleic acid sequence is provided that encodes a chimeric protein comprising a ligand that comprises a naturally occurring or modified follicle stimulating hormone sequence, e.g., an FSHβ sequence, or fragment thereof, which ligand binds to human follicle stimulating hormone (FSH) receptor, linked to either (a) a nucleic acid sequence that encodes an extracellular hinge domain, a transmembrane domain, a co-stimulatory signaling region, and a signaling endodomain; or (b) a nucleic acid sequence that encodes a ligand that binds to NKG2D. The vector containing the nucleic acid sequence, the chimeric proteins so encoded, and modified T cells expressing the chimeric protein, as well as method of using these compositions for the treatment of FSHR-expressing cancers or tumor cells are also provided. | ||
650 | 4 | |a che | |
650 | 4 | |a A61K: Preparations for medical, dental, or toilet purposes (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms a61j0003000000;chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles a61l; soap compositions c11d) | |
650 | 4 | |a C07K: Peptides (peptides containing β-lactam rings c07d;cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, c07d;ergot alkaloids of the cyclic peptide type c07d0519020000; single cell proteins, enzymes c12n;genetic engineering processes for obtaining peptides c12n0015000000) | |
650 | 4 | |a 615 | |
700 | 0 | |a CONEJO-GARCIA JOSE R |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Europäisches Patentamt |g (2021) vom: 03. März |
773 | 1 | 8 | |g year:2021 |g day:03 |g month:03 |
856 | 4 | 0 | |u https://worldwide.espacenet.com/patent/search/family/55631412/publication/EP3200815A1?q=EP3200815 |z kostenfrei |3 Volltext |
912 | |a GBV_EPA | ||
936 | u | w | |j 2021 |b 03 |c 03 |
951 | |a AR | ||
952 | |j 2021 |b 03 |c 03 |