SiRNA pharmaceutical composition for inhibiting various solid tumors
The invention relates to a siRNA (small interfering Ribonucleic Acid) pharmaceutical composition for inhibiting various solid tumors. The siRNA pharmaceutical composition comprises two kinds of siRNA molecules inhibiting expression of different genes, one kind of siRNA inhibits expression of an epidermal growth factor receptor (EGFR), and the other kind of siRNA inhibits expression of a tyrosine protein kinase receptor (MET, also known as a hepatocyte growth factor receptor HGFR). By inhibiting two signal molecules of EGFR and MET, different signal pathways for occurrence and development of solid tumors are influenced, so that a synergistic anti-tumor effect is generated. The siRNA molecular composition provided by the invention can be self-assembled with a nano drug-loading system carrying positive charges to form a nano-particle pharmaceutical preparation, and the pharmaceutical preparation can efficiently inhibit the growth of various solid tumors such as pancreatic cancer, lung cancer, breast cancer, gastric cancer and the like through local and systematic administration..
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Patent| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Europäisches Patentamt - (2023) vom: 05. Mai Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
TANG SHENGGAO [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Themen: |
Sonstige Themen: |
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| Anmerkungen: |
Source: www.epo.org (no modifications made), First posted: 2023-05-05, Last update posted on www.tib.eu: 2023-09-26, Last updated: 2023-09-29 |
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| Patentnummer: |
CN116059235 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
EPA00183780X |
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| 520 | |a The invention relates to a siRNA (small interfering Ribonucleic Acid) pharmaceutical composition for inhibiting various solid tumors. The siRNA pharmaceutical composition comprises two kinds of siRNA molecules inhibiting expression of different genes, one kind of siRNA inhibits expression of an epidermal growth factor receptor (EGFR), and the other kind of siRNA inhibits expression of a tyrosine protein kinase receptor (MET, also known as a hepatocyte growth factor receptor HGFR). By inhibiting two signal molecules of EGFR and MET, different signal pathways for occurrence and development of solid tumors are influenced, so that a synergistic anti-tumor effect is generated. The siRNA molecular composition provided by the invention can be self-assembled with a nano drug-loading system carrying positive charges to form a nano-particle pharmaceutical preparation, and the pharmaceutical preparation can efficiently inhibit the growth of various solid tumors such as pancreatic cancer, lung cancer, breast cancer, gastric cancer and the like through local and systematic administration. | ||
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