Specific Gray Matter Volume Changes of the Brain in Unipolar and Bipolar Depression
To identify the common and specific structural basis of bipolar depression (BD) and unipolar depression (UD) is crucial for clinical diagnosis. In this study, a total of 85 participants, including 22 BD patients, 36 UD patients, and 27 healthy controls, were enrolled. A voxel-based morphology method was used to identify the common and specific changes of the gray matter volume (GMV) to determine the structural basis. Significant differences in GMV were found among the three groups. Compared with healthy controls, UD patients showed decreased GMV in the orbital part of the left inferior frontal gyrus, whereas BD patients showed decreased GMV in the orbital part of the left middle frontal gyrus. Compared with BD, UD patients have increased GMV in the left supramarginal gyrus and middle temporal gyrus. Our results revealed different structural changes in UD and BD patients suggesting BD and UD have different neurophysiological underpinnings. Our study contributes toward the biological determination of morphometric changes, which could help to discriminate between UD and BD..
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2021 |
---|---|
Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
---|---|
Enthalten in: |
Frontiers in Human Neuroscience - 14(2021) |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Junyan Wang [VerfasserIn] |
---|
Links: |
doi.org [kostenfrei] |
---|
Themen: |
Bipolar disorder |
---|
doi: |
10.3389/fnhum.2020.592419 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
DOAJ060982896 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | DOAJ060982896 | ||
003 | DE-627 | ||
005 | 20230501175157.0 | ||
007 | cr uuu---uuuuu | ||
008 | 230228s2021 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.3389/fnhum.2020.592419 |2 doi | |
035 | |a (DE-627)DOAJ060982896 | ||
035 | |a (DE-599)DOAJ6f8e613c60ec48b0952f1ad5e06b1f70 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
050 | 0 | |a RC321-571 | |
100 | 0 | |a Junyan Wang |e verfasserin |4 aut | |
245 | 1 | 0 | |a Specific Gray Matter Volume Changes of the Brain in Unipolar and Bipolar Depression |
264 | 1 | |c 2021 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a Computermedien |b c |2 rdamedia | ||
338 | |a Online-Ressource |b cr |2 rdacarrier | ||
520 | |a To identify the common and specific structural basis of bipolar depression (BD) and unipolar depression (UD) is crucial for clinical diagnosis. In this study, a total of 85 participants, including 22 BD patients, 36 UD patients, and 27 healthy controls, were enrolled. A voxel-based morphology method was used to identify the common and specific changes of the gray matter volume (GMV) to determine the structural basis. Significant differences in GMV were found among the three groups. Compared with healthy controls, UD patients showed decreased GMV in the orbital part of the left inferior frontal gyrus, whereas BD patients showed decreased GMV in the orbital part of the left middle frontal gyrus. Compared with BD, UD patients have increased GMV in the left supramarginal gyrus and middle temporal gyrus. Our results revealed different structural changes in UD and BD patients suggesting BD and UD have different neurophysiological underpinnings. Our study contributes toward the biological determination of morphometric changes, which could help to discriminate between UD and BD. | ||
650 | 4 | |a bipolar disorder | |
650 | 4 | |a unipolar depression | |
650 | 4 | |a gray matter volume | |
650 | 4 | |a voxel-based morphology | |
650 | 4 | |a structural MRI | |
653 | 0 | |a Neurosciences. Biological psychiatry. Neuropsychiatry | |
700 | 0 | |a Junyan Wang |e verfasserin |4 aut | |
700 | 0 | |a Penghong Liu |e verfasserin |4 aut | |
700 | 0 | |a Aixia Zhang |e verfasserin |4 aut | |
700 | 0 | |a Chunxia Yang |e verfasserin |4 aut | |
700 | 0 | |a Sha Liu |e verfasserin |4 aut | |
700 | 0 | |a Jizhi Wang |e verfasserin |4 aut | |
700 | 0 | |a Yong Xu |e verfasserin |4 aut | |
700 | 0 | |a Yong Xu |e verfasserin |4 aut | |
700 | 0 | |a Yong Xu |e verfasserin |4 aut | |
700 | 0 | |a Ning Sun |e verfasserin |4 aut | |
700 | 0 | |a Ning Sun |e verfasserin |4 aut | |
773 | 0 | 8 | |i In |t Frontiers in Human Neuroscience |d Frontiers Media S.A., 2008 |g 14(2021) |w (DE-627)DOAJ000008486 |x 16625161 |7 nnns |
773 | 1 | 8 | |g volume:14 |g year:2021 |
856 | 4 | 0 | |u https://doi.org/10.3389/fnhum.2020.592419 |z kostenfrei |
856 | 4 | 0 | |u https://doaj.org/article/6f8e613c60ec48b0952f1ad5e06b1f70 |z kostenfrei |
856 | 4 | 0 | |u https://www.frontiersin.org/articles/10.3389/fnhum.2020.592419/full |z kostenfrei |
856 | 4 | 2 | |u https://doaj.org/toc/1662-5161 |y Journal toc |z kostenfrei |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_DOAJ | ||
912 | |a SSG-OLC-PHA | ||
951 | |a AR | ||
952 | |d 14 |j 2021 |