FAM83H and Nectin1 expression are related with survival and relapse of bladder urothelial carcinoma patients
Abstract Background FAM83H was originally reported to be essential for dental enamel formation. However, FAM83H has recently been implicated in tumorigenesis and tumor progression. Analysis of a publicly available gene expression database revealed a significant correlation between FAM83H and Nectin1 mRNA expression and bladder urothelial carcinoma (BUC). Therefore, we investigated the association between FAM83H and Nectin1 expression levels and the survival and recurrence of BUC in BUC patients using a tissue microarray. Methods We performed immunohistochemical staining of FAM83H and Nectin1 in 165 human BUC tissue sections, and analyzed the prognostic significance of FAM83H and Nectin1 expression. Results Both FAM83H and Nectin1 were mainly expressed in the cytoplasm, and their expression was significantly associated. FAM83H expression was significantly correlated with higher histologic grade, higher T stage, higher TNM stage, and recurrence. Nectin1 expression was significantly associated with higher histologic grade and recurrence. Univariate analysis showed FAM83H expression and Nectin1 expression were significantly associated with worse overall survival (OS) and shorter relapse-free survival (RFS) of BUC patients. In multivariate analysis, levels of FAM83H and Nectin1 were independent indicators of shorter survival of BUC patients. Conclusions Our results suggest that FAM83H and Nectin1 are important in the progression of BUC, and that expression patterns of these two proteins can be used as prognostic indicators of survival in BUC patients..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:21 |
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| Enthalten in: |
BMC Urology - 21(2021), 1, Seite 11 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ae-Ri Ahn [VerfasserIn] |
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| Links: |
doi.org [kostenfrei] |
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| Themen: |
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| doi: |
10.1186/s12894-021-00908-2 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
DOAJ060160365 |
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| 520 | |a Abstract Background FAM83H was originally reported to be essential for dental enamel formation. However, FAM83H has recently been implicated in tumorigenesis and tumor progression. Analysis of a publicly available gene expression database revealed a significant correlation between FAM83H and Nectin1 mRNA expression and bladder urothelial carcinoma (BUC). Therefore, we investigated the association between FAM83H and Nectin1 expression levels and the survival and recurrence of BUC in BUC patients using a tissue microarray. Methods We performed immunohistochemical staining of FAM83H and Nectin1 in 165 human BUC tissue sections, and analyzed the prognostic significance of FAM83H and Nectin1 expression. Results Both FAM83H and Nectin1 were mainly expressed in the cytoplasm, and their expression was significantly associated. FAM83H expression was significantly correlated with higher histologic grade, higher T stage, higher TNM stage, and recurrence. Nectin1 expression was significantly associated with higher histologic grade and recurrence. Univariate analysis showed FAM83H expression and Nectin1 expression were significantly associated with worse overall survival (OS) and shorter relapse-free survival (RFS) of BUC patients. In multivariate analysis, levels of FAM83H and Nectin1 were independent indicators of shorter survival of BUC patients. Conclusions Our results suggest that FAM83H and Nectin1 are important in the progression of BUC, and that expression patterns of these two proteins can be used as prognostic indicators of survival in BUC patients. | ||
| 653 | 0 | |a Diseases of the genitourinary system. Urology | |
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| 700 | 0 | |a Usama Khamis Hussein |e verfasserin |4 aut | |
| 700 | 0 | |a Ho Sung Park |e verfasserin |4 aut | |
| 700 | 0 | |a Myoung Ja Chung |e verfasserin |4 aut | |
| 700 | 0 | |a Ho Lee |e verfasserin |4 aut | |
| 700 | 0 | |a Woo Sung Moon |e verfasserin |4 aut | |
| 700 | 0 | |a Myoung Jae Kang |e verfasserin |4 aut | |
| 700 | 0 | |a Hyung Jin Kim |e verfasserin |4 aut | |
| 700 | 0 | |a Na Ri Lee |e verfasserin |4 aut | |
| 700 | 0 | |a Kyu Yun Jang |e verfasserin |4 aut | |
| 700 | 0 | |a Kyoung Min Kim |e verfasserin |4 aut | |
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