The interplay between SARS-CoV-2 infected airway epithelium and immune cells modulates regulatory/inflammatory signals
Summary: To assess the cross-talk between immune cells and respiratory tract during SARS-CoV-2 infection, we analyzed the relationships between the inflammatory response induced by SARS-CoV-2 replication and immune cells phenotype in a reconstituted organotypic human airway epithelium (HAE). The results indicated that immune cells failed to inhibit SARS-CoV-2 replication in the HAE model. In contrast, immune cells strongly affected the inflammatory profile induced by SARS-CoV-2 infection, dampening the production of several immunoregulatory/inflammatory signals (e.g., IL-35, IL-27, and IL-34). Moreover, these mediators were found inversely correlated with innate immune cell frequency (NK and γδ T cells) and directly with CD8 T cells. The enriched signals associated with NK and CD8 T cells highlighted the modulation of pathways induced by SARS-CoV-2 infected HAE. These findings are useful to depict the cell-cell communication mechanisms necessary to develop novel therapeutic strategies aimed to promote an effective immune response..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:25 |
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| Enthalten in: |
iScience - 25(2022), 2, Seite 103854- |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Veronica Bordoni [VerfasserIn] |
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| Links: |
doi.org [kostenfrei] |
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| Themen: |
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| doi: |
10.1016/j.isci.2022.103854 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
DOAJ060004304 |
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| 520 | |a Summary: To assess the cross-talk between immune cells and respiratory tract during SARS-CoV-2 infection, we analyzed the relationships between the inflammatory response induced by SARS-CoV-2 replication and immune cells phenotype in a reconstituted organotypic human airway epithelium (HAE). The results indicated that immune cells failed to inhibit SARS-CoV-2 replication in the HAE model. In contrast, immune cells strongly affected the inflammatory profile induced by SARS-CoV-2 infection, dampening the production of several immunoregulatory/inflammatory signals (e.g., IL-35, IL-27, and IL-34). Moreover, these mediators were found inversely correlated with innate immune cell frequency (NK and γδ T cells) and directly with CD8 T cells. The enriched signals associated with NK and CD8 T cells highlighted the modulation of pathways induced by SARS-CoV-2 infected HAE. These findings are useful to depict the cell-cell communication mechanisms necessary to develop novel therapeutic strategies aimed to promote an effective immune response. | ||
| 650 | 4 | |a Immunology | |
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| 700 | 0 | |a Eleonora Cimini |e verfasserin |4 aut | |
| 700 | 0 | |a Alessandra Sacchi |e verfasserin |4 aut | |
| 700 | 0 | |a Eleonora Tartaglia |e verfasserin |4 aut | |
| 700 | 0 | |a Rita Casetti |e verfasserin |4 aut | |
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| 700 | 0 | |a Stefania Notari |e verfasserin |4 aut | |
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| 700 | 0 | |a Gian Maria Fimia |e verfasserin |4 aut | |
| 700 | 0 | |a Maria Rosaria Capobianchi |e verfasserin |4 aut | |
| 700 | 0 | |a Giuseppe Ippolito |e verfasserin |4 aut | |
| 700 | 0 | |a Chiara Agrati |e verfasserin |4 aut | |
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