Clinical Epidemiology : Practice and Methods / edited by Patrick S. Parfrey, Brendan J. Barrett

On Framing the Research Question and Choosing the Appropriate Research Design -- Bias in Clinical Research -- Definitions of Bias in Clinical Research -- Research Ethics for Clinical Researchers -- Ethical, Legal, and Social Issues (ELSI) in Clinical Genetics Research -- Longitudinal Studies 1: Determinants of Risk -- Longitudinal Studies 2: Modeling Data using Multivariate Analysis -- Longitudinal Studies 3: Data Modeling using Standard Regression Models and Extensions -- Longitudinal Studies 4: Matching Strategies to Evaluate Risk -- Longitudinal Studies 5: Development of Risk Prediction Models for Patients with Chronic Disease -- Randomized Controlled Trials 1: Design -- Randomized Controlled Trials 2: Analysis -- Randomized Controlled Trials 3: Measurement and Analysis of Patient-Reported Outcomes -- Randomized Controlled Trials 4: Planning, Analysis, and Interpretation of Quality of Life Studies -- Randomized Controlled Trials 5: Biomarkers and Surrogates/Outcomes -- Randomized Controlled Trials 6: Determining the Sample Size and Power for Clinical Trials and Cohort Studies -- Randomized Controlled Trials 7: On Contamination and Estimating the Actual Treatment Effect -- Evaluation of Diagnostic Tests -- Genetic Epidemiology of Complex Phenotypes -- Qualitative Research in Clinical Epidemiology -- Evidence Based Decision Making 1: Critical Appraisal -- Evidence Based Decision Making 2: Systematic Review and Meta-Analysis -- Evidence-Based Decision Making 3: Health Technology Assessment -- Evidence-Based Decision Making 4: Clinical Practice Guidelines -- Evidence-Based Decision Making 5: Knowledge Translation and the Knowledge to Action Cycle -- Evidence-Based Decision Making 6: Administrative Databases as Secondary Data Source for Epidemiologic and Health Service Research -- Methods in Evidence-Based Decision Making 7: Health Economics in Clinical Research -- Methods in Evidence-Based Decision Making 8: A Primer for Researchers -- Changing Health-Related Behaviors 1: Patient-Oriented Research and Patient Engagement in Health Research -- Changing Health-Care Behaviors 2: On Improving the Value of Health Spending -- Changing Health-Related Behaviors 3: Lessons from Implementation Science -- Changing Health-Related Behaviors 4: Realizing Impact of Health Research through Knowledge Translation -- Changing Health-Related Behaviors 5: On Interventions to Change Physician Behaviors -- Changing Health-Related Behaviors 6: Analysis, Interpretation, and Application of Big Data..

This third edition volume expands on the previous editions with updated chapters on longitudinal studies, randomized trials, evidence-based decisions making, and a new section on changing health-related behaviors. The chapters in this book are organized into six parts: Part One focuses on framing clinical research questions and choosing a suitable design; biases that may occur in clinical research; and the ethics associated with doing conducting research on humans. Parts Two through Four discuss designs, measurements, and analysis that pertain to evaluation of risk in longitudinal studies; assessment of therapy in controlled trials; and evaluation of diagnostic tests. Part Five presents methods used in various components of evidence-based decision-making; and Part Six highlights interventions focused on changing health-related behaviors. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of various types of bias, step-by-step, readily reproducible protocols for different research designs, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Clinical Epidemiology: Methods and Protocols, Third Edition is a valuable resource for clinicians and researchers who want to expand their works to humans and use their findings in the health system..

Medienart:

E-Book

Erscheinungsjahr:

2021.

Erschienen:

New York, NY: Springer US ; 2021.

New York, NY: Imprint: Humana ; 2021.

Ausgabe:

3rd ed. 2021.

Reihe:

Methods in Molecular Biology - 2249

Sprache:

Englisch

Beteiligte Personen:

Parfrey, Patrick S. [HerausgeberIn]
Barrett, Brendan J. [HerausgeberIn]

Links:

doi.org [lizenzpflichtig]

ISBN:

978-1-0716-1138-8

Themen:

Epidemiology.
Molecular biology.

Umfang:

1 Online-Ressource(XIII, 650 p. 90 illus., 37 illus. in color.)

doi:

10.1007/978-1-0716-1138-8

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

1756964955