Stress : genetics, epigenetics and genomics / edited by George Fink

Intro -- Stress: Genetics, Epigenetics, and Genomics: Volume 4: Handbook of Stress -- Copyright -- Contents -- Contributors -- Preface -- References -- Chapter 1: Genetic Dissection of Neuropeptide Circuits Mediating Psychosocial Stress -- Genetic dissection of neural circuits -- Intracerebral Neuropeptide Signaling -- Types of Neuropeptides in the Brain -- Packaging and Trafficking -- Release and Signaling -- Genetic Dissection of Intracerebral Neuropeptide Circuits in Psychosocial Stress -- Overview -- Pioneering Applications -- Conclusions -- References.

Chapter 2: Genetic Variation of HPA Axis Activity and Function in Farm Animals -- Introduction -- Overview of the HPA Axis -- Evidence for Genetic Variability in HPA Axis Activity -- Sources of Genetic Variability -- Approaches to Genetic Mechanisms -- Adrenal Sensitivity to ACTH -- Hormone Bioavailability -- Corticosteroid Hormone Receptors -- Functional Consequences of Genetic Variability -- Perspectives -- References -- Chapter 3: MicroRNAs and the Response to Stress -- Introduction -- miRNA and the Stress Response -- Environmental Pathogens -- Environmental Chemicals.

Physiological Stressors -- Drug Exposures -- MiRNA and the Prenatal Stress Response -- Gestational Stress -- Maternal Immune Activation -- Fetal Alcohol Exposure -- Regulation of the Stress Response by miRNA -- TLR Signaling -- The Cholinergic Antiinflammatory Pathway -- The HPA Axis -- Coordinated miRNA Activity in the Stress Response -- Transgenerational Effects of Stress on miRNA -- Conclusions and Perspectives -- References -- Chapter 4: Stress-Mediated Regulation of the DNA Methylome -- Introduction -- Epigenetics -- DNA Methylation -- Stress-Induced Modulation of the DNA Methylome.

Prenatal Stress -- Early Postnatal Stress -- Postnatal Stress -- Future Directions -- Conclusions -- References -- Chapter 5: Genomics and Epigenetics of Plant Abiotic Stress -- Introduction -- An Overview of Plant Stress Responses -- The SOS Pathway is Central to Salt Stress Signaling -- Drought Stress Signaling is Regulated by ABA -- MAPing the Osmotic Stress Response -- Temperature Stress: (Transcription) Factor in the Hot and Cold -- ROS-Calcium Interplay: Biotic Stress -- The More, Less Merrier?: Multistress Cross Talk for Improved Tolerance.

Genomics Assisted Breeding for Plant Stress Tolerance -- Looking at Stress Through Epigenetic Lenses -- Exploring Epigenetics for Developing Stress Tolerance -- Future Perspectives -- References -- Chapter 6: The Long-Term Biological and Clinical Consequences of Child Abuse and Neglect -- Introduction -- Epidemiology -- Bullying -- PTSD -- Sexual Abuse and Suicide -- Mood Disorders -- Eating Disorders -- Substance Use -- Health-Harming Behaviors -- Pregnancy -- Preclinical Studies -- Inflammation and Risk for Metabolic Disorders -- Endocrine Systems -- Genetics -- Serotonin Transporter (5-HTT).

Medienart:

E-Book

Erscheinungsjahr:

2020

Erschienen:

San Diego: Elsevier Science & Technology ; 2020

Reihe:

Handbook of Stress - Volume 4

Sprache:

Englisch

Beteiligte Personen:

Fink, George [HerausgeberIn]

Links:

Volltext [lizenzpflichtig]
Volltext [lizenzpflichtig]

ISBN:

978-0-12-813157-2

0-12-813157-8

Themen:

�Epig�en�etique
Epigenetics
G�enomique
Genomics
Stress
Stress (Physiology)

Anmerkungen:

Description based upon print version of record

FKBP5

Umfang:

1 Online-Ressource

doi:

10.1016/C2016-0-04613-2

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

1738082067