Nutzung additiver Fertigungstechnologien zur Entwicklung von Darreichungsformen für die lokale Applikation von Arzneistoffen / vorgelegt von Malte Bogdahn ; 1. Gutachter: Prof. Dr. Werner Weitschies, 2. Gutachter: Prof. Dr. Jörg Breitkreutz
Arzneiform, Fused Deposition Modeling, Pharmazeutische Technologie, Pharmazie, Rapid Prototyping <Fertigung>, Tablette, 3D-Druck.
The aim of this PhD thesis was to develop dosage forms with new drug release mechanism relying on gastro intestinal motility. The production of these objects additive manufacturing techniques, more precisely a fused deposition modeling process should be developed and established for pharmaceutical use. A 3d printer was modified to use pharmaceutical polymers as raw material. The polymers were converted into filaments by an specially designed apparatus. The mechanics of the used 3d printers were adopted to meet the requirements for the use of brittle pharmaceutical polymers. Eudragit ® RS could be used to manufacture pressure sensitive dosage forms. To overcome the limitations of readily available slicing software an optimized script was programmed to generate the gcode used to control the printer and thereby alter drug release parameter such as gastro intestinal pressure. These processes were investigated and optimized using commercially available PLA filament. Afterwards the processes were transferred to Eudragit ® Filament. Three batches of pressure sensitive dosage forms were manufactured and their release profiles were investigated. It was shown that drug release was triggered by different pressures. The developed release mechanism could be used to apply drug containing films on the intestinal mucosa. The geometry of objects manufactured by additive manufacturing processes con the freely varied in brought ranges. The influence of the geometry on the release profile of ....
| Medienart: |
E-Book |
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| Erscheinungsjahr: |
07.02.2019 |
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| Erschienen: |
Greifswald: 07.02.2019 |
| Weitere Ausgaben: |
Erscheint auch als Druck-Ausgabe: Nutzung additiver Fertigungstechnologien zur Entwicklung von Darreichungsformen für die lokale Applikation von Arzneistoffen |
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| Sprache: |
Deutsch |
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| Beteiligte Personen: |
Bogdahn, Malte [VerfasserIn] |
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| Hochschulschrift: |
Dissertation, Mathematisch-Naturwissenschaftliche Fakultät der Universität Greifswald, 2019 |
| Links: |
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| BKL: | |
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| Themen: |
3D-Druck |
| Anmerkungen: |
Literaturverzeichnis: Seite 115-125 |
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| Umfang: |
1 Online-Ressource (PDF-Datei: 150 Seiten, 23503 Kilobyte) ; Illustrationen (farbig), Diagramme (teilweise farbig) |
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| Weitere IDs: |
urn:nbn:de:gbv:9-opus-27137 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
1666821012 |
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| 520 | |a The aim of this PhD thesis was to develop dosage forms with new drug release mechanism relying on gastro intestinal motility. The production of these objects additive manufacturing techniques, more precisely a fused deposition modeling process should be developed and established for pharmaceutical use. A 3d printer was modified to use pharmaceutical polymers as raw material. The polymers were converted into filaments by an specially designed apparatus. The mechanics of the used 3d printers were adopted to meet the requirements for the use of brittle pharmaceutical polymers. Eudragit ® RS could be used to manufacture pressure sensitive dosage forms. To overcome the limitations of readily available slicing software an optimized script was programmed to generate the gcode used to control the printer and thereby alter drug release parameter such as gastro intestinal pressure. These processes were investigated and optimized using commercially available PLA filament. Afterwards the processes were transferred to Eudragit ® Filament. Three batches of pressure sensitive dosage forms were manufactured and their release profiles were investigated. It was shown that drug release was triggered by different pressures. The developed release mechanism could be used to apply drug containing films on the intestinal mucosa. The geometry of objects manufactured by additive manufacturing processes con the freely varied in brought ranges. The influence of the geometry on the release profile of ... | ||
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